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CAS 51899-07-1 Calcium 3-hydroxybutyrate (BHBCalcium) Synthetic Compound with C8H14CaO6 Formula Exogenous Ketone Supplements

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Calcium 3-hydroxybutyrate CAS 51899-07-1

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CAS 51899-07-1 phospholipid chemical

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C8H14CaO6 Synthetic Calcium 3-hydroxybutyrate

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Product Description
Calcium 3-hydroxybutyrate CAS: 51899-07-1
Product Overview

Calcium 3-hydroxybutyrate is a synthetic compound with the chemical formula C8H14CaO6, identified by CAS number 51899-07-1.

Chemical Specifications
Chemical Name Calcium 3-hydroxybutyrate
CAS Number 51899-07-1
Molecular Formula C8H14CaO6
EINECS Number 000-000-0
Biological Source Synthetic
Structural Formula
CAS 51899-07-1 Calcium 3-hydroxybutyrate (BHBCalcium)  Synthetic Compound with C8H14CaO6 Formula Exogenous Ketone Supplements 0
Synonyms
(R)-3-Hydroxybutanoic acid calcium salt; Calcium 3-hydroxybutyrate; calcium 3-hydroxybutanoate; DL-3-HYDROXYBUTYRIC ACID Calcium SALT; BHB Calcium; Beta hydroxybutyrate Calcium; Calcium, bis(3-hydroxybutanoato-O1,O3)-,(T-4); Calcium 3-hydroxybutyrate Salts

1. Metabolic Role

BHB serves as an alternative energy substrate when glucose availability is limited. During periods of:

  • Fasting or starvation

  • Prolonged exercise

  • A ketogenic (low-carb, high-fat) diet

the liver converts fatty acids into ketone bodies, with BHB being the most abundant and stable form. It is transported via the bloodstream to extrahepatic tissues (particularly the brain, heart, and skeletal muscle), where it is converted back to acetyl-CoA and enters the citric acid cycle to produce ATP (energy).

Unlike fatty acids, BHB can cross the blood-brain barrier, making it a critical fuel source for the brain during glucose scarcity.

2. Chemical Forms

In commercial and research contexts, 3-hydroxybutyrate is typically encountered in two forms:



Form Description
Free acid The pure compound (C₄H₈O₃), rarely used directly due to acidity
Salts (ketone salts) Combined with minerals such as sodiummagnesiumcalcium, or potassium to improve palatability and provide electrolyte support

The most common salts include:

  • Sodium 3-hydroxybutyrate (CAS 150-83-4)

  • Magnesium 3-hydroxybutyrate (CAS 163452-00-4)

  • Calcium 3-hydroxybutyrate (CAS 51899-07-1)

3. Exogenous Ketone Supplements

In recent years, exogenous ketone supplements have gained popularity. These products deliver BHB (usually as mineral salts) directly to the body, aiming to:

  • Induce ketosis without strict dietary restriction

  • Enhance cognitive and physical performance

  • Reduce appetite

  • Mitigate symptoms of "keto flu" during the transition to a ketogenic diet

4. Research and Potential Benefits

Scientific interest in BHB extends beyond energy metabolism:



Area Key Findings
Neuroprotection Animal studies suggest BHB may protect against neurodegeneration (e.g., in Alzheimer's, Parkinson's, and stroke models) by reducing oxidative stress and inflammation
Metabolic health May improve insulin sensitivity and support weight management
Athletic performance Mixed results; some studies show benefits in endurance, while others report gastrointestinal distress without performance gains
Heart failure Emerging research indicates BHB may improve cardiac efficiency and outcomes in heart failure patients

5. Safety and Regulatory Status

Despite its natural occurrence in the body, the safety of long-term, high-dose exogenous BHB supplementation remains under evaluation.

  • EFSA (European Food Safety Authority) : In 2022, EFSA concluded that the available data on ketone salts (including BHB magnesium and calcium) were insufficient to establish safe intake levels for use as novel foods.

  • Common side effects : Gastrointestinal discomfort (nausea, bloating, diarrhea) and potential electrolyte imbalances if consumed in excess.