Broad-Spectrum Industrial Biocide and Preservative CAS 26172-55-4 for Water Treatment and More
| Menyoroti | Broad-Spectrum Industrial Biocide,CAS 26172-55-4 Preservative,Water Treatment Isothiazolinone |
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|---|---|---|---|
| CAS Number | 26172-55-4 |
| EINECS | 247-500-7 |
| Chemical Name | 5-Chloro-2-methyl-4-isothiazolin-3-one |
Isothiazolone derivatives are compounds containing an isothiazolone ring, representing a new class of broad-spectrum, highly effective non-oxidizing fungicides. Known for their high efficiency, environmental compatibility, and broad-spectrum properties, these biocides are widely used in industrial circulating cooling water, adhesives, textiles, coatings, emulsions, plastics, paper manufacturing, and various other fields.
- Cooling water systems
- Oilfield injection water
- Paper mill white water
- Reverse osmosis membranes
Typical dosage: 80-300 mg/L
- Latex paints
- Waterborne industrial coatings
- Wood stains
- Plasters and mortars
Typical dosage: 0.05-0.4% of active ingredient
- Cutting fluids
- Grinding fluids
- Hydraulic fluids
Typical dosage: 0.1-0.2% (MIT/CMIT blends)
- Water-based adhesives
- Caulks and sealants
- Joint compounds
- Shampoos, conditioners (rinse-off products)
- Liquid soaps
- Wet wipes
- Makeup removers
EU: MIT banned in leave-on products; MIT in rinse-off products ≤ 0.0015%; CMIT/MIT mixtures prohibited in leave-on products
China: Similar restrictions under GB/T 29666-2013
- Liquid detergents
- Fabric softeners
- All-purpose cleaners
- Dishwashing liquids
- Leather tanning preservation
- Textile finishing
- Anti-mildew treatments
- Ship hull paints
- Marine structures
- Fishing nets
- Seed treatment
- Rice blast control (patented uses)
| Hazard Type | Description |
|---|---|
| Skin Sensitization | Strong contact allergen; most significant concern; sensitization can develop after repeated exposure |
| Skin Irritation | Irritating to skin; prolonged contact may cause chemical burns |
| Eye Damage | Causes serious eye damage (Category 1) |
| Respiratory Sensitization | Inhalation may cause asthma-like reactions (occupational hazard reported) |
| Acute Toxicity | Oral LD50 (rat): ~1000-1400 mg/kg (moderately toxic); dermal LD50 (rabbit): >2000 mg/kg |
| Endpoint | Value |
|---|---|
| Oral LD50 (rat) | 1,000-1,400 mg/kg |
| Dermal LD50 (rabbit) | >2,000 mg/kg |
| Inhalation LC50 (rat) | 2.6-3.4 mg/L (4h) |
| Eye Irritation | Corrosive (causes irreversible damage) |
| Skin Irritation | Severe irritant |
| Skin Sensitization | Strong sensitizer (potency: moderate to strong) |
Isothiazolinones are highly toxic to aquatic organisms:
| Endpoint | Value |
|---|---|
| Fish (LC50) | 0.1-1.0 mg/L (96h) |
| Daphnia magna (EC50) | 0.05-0.5 mg/L (48h) |
| Algae (EC50) | 0.01-0.1 mg/L (72h) |
| Region | Classification |
|---|---|
| GHS | Acute Tox. 4 (Oral), Skin Corr. 1B/1C, Eye Dam. 1, Skin Sens. 1, Aquatic Acute 1 |
| EU CLP | H302 (Harmful if swallowed), H314 (Causes severe skin burns and eye damage), H317 (May cause an allergic skin reaction), H400 (Very toxic to aquatic life) |
| US EPA | Registered pesticide; subject to FIFRA regulations |
| EU BPR | Approved biocidal active substance; usage restricted under Biocidal Products Regulation (EU) 528/2012 |
| Cosmetics Regulation | EU: MIT ≤ 0.0015% (rinse-off only); CMIT/MIT mixtures prohibited in leave-on products; BIT and OIT banned in cosmetics |
